Description

Poly‑L‑Glutamic Acid / Sodium Poly‑L‑Glutamate (PLE)
CAS: 25513‑46‑6 (free acid), 26247‑79‑0 (sodium salt)
White crystalline powder with excellent water solubility. Available in L‑, D‑, and DL‑forms, molecular weight 3,000–80,000 Da, custom high‑MW grades supported.
Produced via optimized NCA ring‑opening polymerization with zero metal catalyst, PDI ≤1.15 for batch‑to‑batch consistency. Purified by dialysis, sterile filtered and lyophilized for medical‑grade quality.
As a natural‑like anionic polyamino acid with dense carboxyl side groups, it features high water retention, low immunogenicity and full biodegradability. Widely used for HA hydrogel modification, injectable aesthetic fillers, skin repair dressings, gene delivery carriers and layer‑by‑layer coatings.
Applications: Dermal fillers, anti‑aging biomaterials, hydrogel matrix, drug delivery, tissue engineering, surface coating






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